Kidney and Pancreas Transplantation
The Kidney and Pancreas Transplantation group of the University of Padova is the highest volume center in Italy for Kidney Transplantation, with the largest experience in living donor transplantation and mini-invasive techniques for donor nephrectomies.
The group is involved in the most significant international multicentric clinical trials for the development of new immunosuppressive therapies.
The research topics are primarily:
Evaluation and utilization of ECD and dual kidney transplantation
Hypothermic and normothermic kidney machine perfusion
Access to transplantation for sensitized recipients
AB0 incompatible and HLA incompatible kidney transplantation
Kidney paired exchange
SARS-CoV 2 infection in immunocompromised patients
Pancreas transplantation
Islet transplantation and islet autotransplantation
Mini-invasive (laparoscopic) nephrectomies in ADPKD patients pre or post-transplantation
Research activities
1) Therapeutic desensitization approach in hyperimmune patients for kidney transplantation
2) Microencapsulation of beta cells for islet transplantation immunosuppression free
3) Dgf in kidney transplantation
4) Remote platform development for glycemic monitoring of type 1 diabetes patients undergoing islet transplantation
5) Novel biomarkers for renal function
6) Human islet transplantation in a model of type 1 Diabetes in immunodeficient NOD/SCID mice: assessment of potency of different islet purification fractions in autologous and allogenic transplantation
Selected publications:
- Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus.
Furian L, Heemann U, Bengtsson M, Bestard O, Binet I, Böhmig GA, Boletis J, Briggs D, Claas FHJ, Couzi L, Cozzi E, Crespo M, De Vries APJ, Diekmann F, Durlik M, Glotz D, Helantera I, Jackson A, Jordan SC, Kuypers D, Lefaucheur C, Legendre C, Lorant T, Maggiore U, Mamode N, Marinaki S, Massart A, Müller T, Oberbauer R, Renders L, Roelen D, Taupin JL, Viklický O, Vittoraki A, de Weerd AE, Naesens M.
Transpl Int. 2025 Jan 6;37:13886. doi: 10.3389/ti.2024.13886. eCollection 2024. PMID: 39867871 - European Survey on Clinical Practice of Detecting and Treating T-Cell Mediated Kidney Transplant Rejection.
Koshy P, Furian L, Nickerson P, Zaza G, Haller M, de Vries APJ, Naesens M.
Transpl Int. 2024 Apr 18;37:12283. doi: 10.3389/ti.2024.12283. eCollection 2024.
PMID: 38699173 Free PMC article - European Consensus on the Management of Sensitized Kidney Transplant Recipients: A Delphi Study.
Furian L, Bestard O, Budde K, Cozzi E, Diekmann F, Mamode N, Naesens M, Pengel LHM, Schwartz Sorensen S, Vistoli F, Thaunat O.
Transpl Int. 2024 Apr 11;37:12475. doi: 10.3389/ti.2024.12475. eCollection 2024. PMID: 38665475 - European Society for Organ Transplantation (ESOT)-TLJ 3.0 Consensus on Histopathological Analysis of Pre-Implantation Donor Kidney Biopsy: Redefining the Role in the Process of Graft Assessment.
Zaza G, Cucchiari D, Becker JU, de Vries APJ, Eccher A, Florquin S, Kers J, Rabant M, Rossini M, Pengel L, Marson L, Furian L.
Transpl Int. 2023 Jul 4;36:11410. doi: 10.3389/ti.2023.11410. eCollection 2023. PMID: 37470063 Free PMC article. - Robotic Versus Laparoscopic Donor Nephrectomy: A Retrospective Bicentric Comparison of Learning Curves and Surgical Outcomes From 2 High-volume European Centers.
Centonze L, Di Bella C, Giacomoni A, Silvestre C, De Carlis R, Frassoni S, Franchin B, Angrisani M, Tuci F, Di Bello M, Bagnardi V, Lauterio A, Furian L, De Carlis L.
Transplantation. 2023 Sep 1;107(9):2009-2017. doi: 10.1097/TP.0000000000004618. Epub 2023 Aug 21. PMID: 37195281
Funding
- Fondazione Veneta per la Terapia Cellulare del Diabete TCD: Founded on November 9, 2022, it was established to support the activities of the Center for Cellular Therapy of Diabetes, inaugurated in 2021 at the Hospital-University of Padua. Its goal is to initiate, in the Veneto region, a pancreatic islet transplantation program for patients with type 1 diabetes (insulin-dependent). https://www.fondazionetcd.org/
- Cassa di Risparmio Foundation of Padua and Rovigo contributed to the funding of the three-year project on microencapsulated islet transplantation, titled ""MICROENCAPSULATED ISLET TRANSPLANTATION: A PATH TOWARDS A LIFE WITHOUT INSULIN AND WITHOUT IMMUNOSUPPRESSION IN TYPE 1 DIABETIC PATIENTS (IF2 STUDY),"" which the Regional Center for Diabetes Cell Therapy is working on.
People involved:
Lucrezia Furian (Full Professor)
Caterina Di Bella (Assistant Professor)
Mattia Albiero (Assistant Professor)
Group members:
Consultant Surgeons:
Marianna di Bello, MD
Cristina Silvestre, MD, PhD
Francesco Tuci, MD
Islet transplantation facility:
Adolfo Paolin,
Lucia Rizzato
Roberta Cappellari
Massimo Menegazzo
Erica Nuzzolese
Verdiana Ravarotto
Veronica Bedin
