Immune-mediated disorders refer a group of conditions which are characterized by common inflammatory pathways leading to inflammation, and which may result from, or be triggered by, a dysregulation of the typical immune response. In the last years, we are focusing our research in this group of diseases, including eosinophilic esophagitis, autoimmune gastritis, coeliac disease and inflammatory bowel diseases (Crohn’s disease and ulcerative colitis). We aim to comprehensively and systematically characterize mechanisms of immune dysregulation that contribute to their pathogenesis; to identify possible contributions of environmental factors, including eating habits; to identify and validate new therapeutic targets; to evaluate the effect of these conditions on the quality of life and work disability.

Publications:

Visaggi P, Barberio B, Del Corso G, de Bortoli N, Black CJ, Ford AC, Savarino E.
Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis.
Gut. 2023 Nov;72(11):2019-2030

Crepaldi M, Maniero D, Massano A, Pavanato M, Barberio B, Savarino EV, Zingone F.
Azathioprine monotherapy withdrawal in inflammatory bowel diseases: A retrospective mono-centric study.
World J Gastroenterol. 2023 Jul 21;29(27):4334-4343. doi: 10.3748/wjg.v29.i27.4334.

Ciacci C, Bai JC, Holmes G, Al-Toma A, Biagi F, Carroccio A, Ciccocioppo R, Di Sabatino A, Gingold-Belfer R, Jinga M, Makharia G, Niveloni S, Norman GL, Rostami K, Sanders DS, Smecuol E, Villanacci V, Vivas S, Zingone F; Bi.A.CeD study group.
Serum anti-tissue transglutaminase IgA and prediction of duodenal villous atrophy in adults with suspected coeliac disease without IgA deficiency (Bi.A.CeD): a multicentre, prospective cohort study.
Lancet Gastroenterol Hepatol. 2023 Nov;8(11):1005-1014

Bertin L, Crepaldi M, Zanconato M, Lorenzon G, Maniero D, de Barba C, Bonazzi E, Facchin S, Scarpa M, Ruffolo C, Angriman I, Buda A, Zingone F, Barberio B, Savarino EV. Advancing therapeutic frontiers: a pipeline of novel drugs for luminal and perianal Crohn's disease management.
Therap Adv Gastroenterol. 2024 Dec 19;17:17562848241303651. doi: 10.1177/17562848241303651.

Zingone F, Marsilio I, Fassan M, Pilotto V, Maddalo G, Lorenzon G, Savarino EV, Farinati F.
Duodenal Histological Findings and Risk of Coeliac Disease in Subjects with Autoimmune Atrophic Gastritis: A Retrospective Evaluation.
Digestion. 2021;102(4):615-621. doi: 10.1159/000510354.

Funding:

2008 - Title of The Research Project “Pathogenic Mechanisms And Common Therapeutic Strategies In the Immune-Related Dermatopathies Associated To Chronic Enteropathies” Funded by Italian Ministry of Instruction, Research and University – PRIN 2008

2016 - Title of The Research Project “Impact of Chronicity on Disability State and Quality of Life in Patients with Ulcerative Colitis” Funded by the Italian Group of Inflammatory Bowel Disease (IG-IBD)

2020 (PI) – SID: Title of The Research Project “The role of oxidative stress in coeliac disease” - Department of Surgery, Oncology and Gastroenterology - DiSCOG

2023 (PI) – DOR: Title of The Research Project “Azathioprine therapy in Inflammatory Bowel Diseases: a retrospective mono-centric study” – Department of Surgery, Oncology and Gastroenterology - DiSCOG

2024 (PI) – SID: Title of The Research Project “Biomarkers of the Future: Celiac Disease Monitoring” – Department of Surgery, Oncology and Gastroenterology - DiSCOG

People involved:

Edoardo V. Savarino, Associate Professor
Imero Angriman, Associate Professor
Fabiana Zingone, Associate Professor
Marco Scarpa, Assistant Professor

Group members:

Anna D’Odorico, Francesca Galeazzi, Brigida Barberio (Consultant Gastroenterologists), Cesare Ruffolo (Consultant Surgeon), Sonia Facchin, Erica Bonazzi, Daria Maniero, Michela Palo, Elena Agostini (Research Fellows), Greta Lorenzon (Study Coordinator and Research Nurse)