Overview of the research line

The main lines of research of the group included:

Genetic susceptibility to pancreatic cancer, chronic pancreatitis and neuroendocrine pancreatic tumors and their functional characterization.

Study cohordinated by a Genomic Epidemiology group from Heidelberg joint in an European consortium named PANDoRA. Head of the Padua Research Unit : Prof. C. Pasquali

Development of an integrate management of patients with Multiple Endocrine Neoplasms type 1.

Multimodal treatment of metastatic neuroendocrine pancreatic neoplasms and evaluation of benefit of R2 resections.

Multimodal treatment of metastatic neuroendocrine small intestinal tumors: role of surgery and evaluation of quality of life after surgery (joint project with Endocrine Surgery – Lund , Sweden)

Ampullary neoplasms and rare variety of ampullary tumors. Molecular biology markers of behaviour (joint project with Humanitas Research Hospital- Milan)

Biological markers of pancreatic cancer and relationship with diabetes.

Role of surgery in the treatment of metastases of pancreas

Retrospective multicentric study on atypical pancreatic resection in Neuroendocrine pancreatic Neoplasms. (joint project with the European Pancreatic cancer Center – Heidelberg)

5 publications

Campa D., Pastore M.,Capurso G., Hackert T., Di Leo M., Izbicki J. R., Kay-Tee Khaw, Gioffreda D., Kupcinskas J., PASQUALI C., Macinga P., Kaaks R., Stigliano S., Peeters P.H., Key T.J., Talar-Wojnarowska R., Vodicka P., Valente R, Vashist Y.K., Salvia R., Papaconstantinou I., Shimizu Y., Valsuani C., Zambon C. F.,Gazouli M., Valantiene I., Niesen W., Mohelnikova-Duchonova B.,Hara K., Soucek P., Malecka-Panas E., Bueno-de-Mesquita B.H., Johnson T., Brenner H., Tavano F., Fogar P., Ito H., Sperti C., Butterbach K., Latiano A., Andriulli A., Cavestro G. M., Busch O.R., Dijk F., Greenhalf W., Matsuo K., Lombardo C., Strobel O., König A.-K., Cuk K., Strothmann H., Katzke V., Cantore M., Mambrini A.,Oliverius M., Pezzilli R., Landi S., Canzian F.: Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. Int J Cancer 142:290-296, 2018.doi 10.1002/ijc.31047

Campa D., Obazee O., Pastore M., Panzuto F. , Liço V , Greenhalf W, Katzke V.A., Tavano F., Costello  E., Corbo V. , Talar-Wojnarowska R., Strobel O., Zambon C.F., Neoptolemos J.P., Zerboni G, Kaaks R., Key T.J., Lombardo C., Jamroziak K., Gioffreda D., Hackert T., Khaw K.T., Landi S., Milanetto A.C. , Landoni L., Lawlor R. T., Bambi F., Pirozzi F., Basso D., PASQUALI C., Capurso G.: Lack of association for the reported endocrine pancreatic cancer risk loci in the PANDoRA consortium. Cancer Epidemiology, Biomarkers & Prevention 26:1349-1351, 2017. doi: 10.1158/1055-9965. EPI-17-0075

Campa D., Capurso G., Pastore M., Talar-Wojnarowska R., Milanetto A.C., Landoni L., Maiello E., Lawlor R.T., Malecka-Panas E., Funel N., Gazouli M., De Bonis A., Klüter H., Rinzivillo M., Delle Fave G., Hackert T., Landi S., Bugert P., Bambi F., Archibugi L., Scarpa A., Katzke V., Dervenis C., Liço V., Furlanello S., Strobel O., Tavano F., Basso D., Kaaks R., PASQUALI C., Gentiluomo M., Rizzato C., Canzian F.: Common germline variant within the CDKN2A/2B region affect risk of pancreatic neuroendocrine tumors. Sci Rep 6:39565, 2016 doi: 10.1038/srep39565.

Campa D., Pastore M., Gentiluomo M., Talar-Wojnarowska R., Kupcinskas  J., Malecka-Panas E., Neoptolemos J.P., Niesen W., Vodicka P., Delle Fave G., Bas Bueno-deMesquita G., Gazouli M., Pacetti P., Di Leo M., Ito H., Klüter H., Soucek P., Corbo V., Yamao K., Hosono S., Kaaks R., Vashist Y., Gioffreda D., Strobel O., Shimizu Y., Dijk F., Andriulli A., Ivanauskas A., Bugert P., Tavano F., Vodickova L., Zambon C. F., Lovecek M., Landi S., Key T.J., Boggi U., Pezzilli R., Jamroziak K., Mohelnikova-Duchonova B., Mambrini A., Bambi F., Busch O., Pazienza V., Valente R., Theodoropoulos G.E., Hackert T., Capurso G.,  Cavestro G.M., PASQUALI C., Basso D., Sperti C., Matsuo K., Büchler M., Khaw K.-T., Izbicki J., Costello E., Katzke V., Michalski C., Stepien A., Rizzato C., Canzian F.: Functional single nucleotide polymorphisms within the cyclin dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk. Oncotarget, 7(35):57011-57020, 2016 doi: 10.18632/oncotarget.10935
 
Rizzato C., Campa D., Talar-Wojnarowska R., Halloran C., Kupcinskas J., Butturini G., Mohelníková-Duchonová B., Sperti C., Tjaden C., Ghaneh P., Hackert T., Funel N., Giese N., Tavano F., Pezzilli R., Pedata M., PASQUALI C., Gazouli M., Mambrini A., Souček P., Di Sebastiano P., Capurso G., Cantore M., Oliverius M., Offringa R., Małecka-Panas E., Strobel O., Scarpa A., Canzian F.: Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients. Carcinogenesis, 37(10):957-64, 2016.doi 10.1093/carcin/bgw080.

Funding

Ipsen S.p.A. 2017: Euro 15.000 (Research Grant)
Private 2017 : Euro 5.000 (for Research)

People involved:

Pasquali Claudio Associate Professor DiSCOG
Fassan Matteo Associate Professor  DiMED
Basso Daniela Associate Professor DiMED

Group members

Post-Doc: Milanetto Anna Caterina DiSCOG
Other grants : Menato Riccardo DiSCOG
Azienda Ospedaliera : Martini Chiara M.D. Clinica Medica 3
Azienda Ospedaliera: De Carlo Eugenio M.D. Clinica Medica 3