Surgery of colorectal cancer

Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of death from cancer. For the past 20 years, our research group has been investigating on multiple aspects of CRC, from early diagnosis to surgical treatment. The main field of research is related to rectal cancer and the association with neoadjuvant treatment (NT) performing both translational and clinical researches.

We mostly focus on:

Investigation of multiple and non-invasive predictive factors after NT, e.g. serum telomerase (hTERT), miRNA and microarrays;

Application of rectal sparing approaches (local excision) in patients with complete or major clinical response undergone NT and investigation of surgical and oncological outcomes. Currently the group is running a multicentre prospective trial called Resarch;

Quality of life and bowel function in rectal cancer patients undergoing NT and/or rectal surgery;

Rectal cancer staging and re-staging with selective radiological techniques, as PET-MRI, for understanding predictive elements of response to NT or local recurrence;

Relation between high-volume hospital for rectal cancer care and oncological, surgical and economic outcomes;

Surgical approach, early diagnosis and surveillance of hereditary colorectal cancer (FAP, a-FAP, HNPCC).


Pucciarelli S et al. Relationship between hospital volume and short-term outcomes: a nationwide population-based study including 75,280 rectal cancer surgical procedures. Oncotarget. 2018;9:17149-59.

Pucciarelli S et al. Bowel function and quality of life after local excision or total mesorectal excision following chemoradiotherapy for rectal cancer. Br J Surg. 2017;1:138-47

Barina A et al. Rectal sparing approach after preoperative radio- and/or chemotherapy (RESARCH) in patients with rectal cancer: a multicentre observational study. Tech Coloproctol. 2017;8:633-40

Maas M et al. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol. 2010;11:835-44

Guillem JG et al. cT3N0 rectal cancer: Potential overtreatment with Preoperative chemoradiotherapy is warranted. J Clin Oncol. 2008;26:368-73

People involved:

Pucciarelli Salvatore, MD (Full Professor, Clinica Chirurgica 1)

Group Member

Urso EDL, MD (Staff, Clinica Chirurgica 1)
Maretto Isacco, MD (Staff, Clinica Chirurgica 1)
Perin Alessandro, MD (Staff, Ospedale Sant’Antonio)
Toppan Paola, MD (Staff, Clinica Chirurgica 1)
Giandomenico Francesca (Psychologist, Clinica Chirurgica 1)
Spolverato Gaya (Research Fellow at the MSKCC of New York)
Bushati Matilda, MD (Resident, Clinica Chirurgica 1)
Barina Andrea, MD (Resident, Clinica Chirurgia 1)
Zuin Matteo, MD (Resident, Clinica Chirurgica 1)
Marchegiani Francesco, MD (Resident, Clinica Chirurgica 1)