Lucrezia Furian.pdf

- Use of Celsior solution for swine pancreas preservation, in the Center of Experimental Surgery of the University of Padova.
- Application of the magnetic resonance spectroscopy with deuterium in a rat model for evaluating organs viability after warm ischemia, in the Center of Biophysical Sciences of the University of Padova.
- Basic research in tolerance induction and signal transduction pathways, with particular interest on IL-2 receptor signaling inhibition  by antisense technology, new immunosuppressive drugs (Jak3 inhibitors), and murine models of humoral and cellular rejection in Stat4,5 a/b, 6 knock out.
- Pig to primate xenotransplantation, in the program promoted by Imutran.
- Experimental surgery in pig models of renal and pancreatic transplantation.
- Clinical research in immunosuppressive drugs and protocols, desensitization strategies for AB0 incompatibility and sensitized kidney transplant recipients, Kidney paired donation

1. Angriman I, Furian L, Scarpa M, Fassan M, Morgan S, Porzionato A, Kotsafti A, Saadeh L, Silvestre C, De Caro R, Carraro A, Tedeschi U, Bardini R, Rigotti P, Rugge M, Castoro C, Castagliuolo I, Scarpa M. Effects of immune suppression for transplantation on inflammatory colorectal cancer progression.Oncogenesis. 2018 Jun 19;7(6):46.

2. Furian L, Rigotti P.Transplantation: Optimizing outcomes in elderly kidney transplant recipients. Nat Rev Nephrol. 2013 Jul;9(7):382-4

3. Chen W, Langer RM, Janczewska S, Furian L, Geary R, Qu X, Wang M, Verani R, Condon T, Stecker K, Bennett CF, Stepkowski SM. Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation. 2005 Feb 27;79(4):401-8. IF=3.608

4. Stepkowski SM, Kao J, Wang ME, Tejpal N, Podder H, Furian L, Dimmock J, Jha A, Das U, Kahan BD, Kirken RA The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities. J Immunol. 2005 Oct 1;175(7):4236-46. IF=6.702

5. Zhang Y, Kirken RA, Furian L, Janczewska S, Qu X, Hancock WW, Wang M, Tejpal N, Kerman R, Kahan BD, Stepkowski SM. Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells. J Immunol. 2006 Jan 1;176(1):128-37

6. Graziotto R, Del Prete D, Rigotti P, Anglani F, Baldan N, Furian L, Valente M, Antonello A, Marchini F, D'Angelo A, Gambaro G. Perforin, Granzyme B, and fas ligand for molecular diagnosis of acute renal-allograft rejection: analyses on serial biopsies suggest methodological issues. Transplantation. 2006 Apr 27;81(8):1125-32

7. Ruggenenti P, Silvestre C, Boschiero L, Rota G, Furian L, Perna A, Rossini G, Remuzzi G, Rigotti P. Long-term outcome of renal transplantation from octogenarian donors: A multicenter controlled study. Am J Transplant. 2017 Dec;17(12):3159-3171

8. Neri F, Furian L, Cavallin F, Ravaioli M, Silvestre C, Donato P, La Manna G, Pinna AD, Rigotti P. How does age affect the outcome of kidney transplantation in elderly recipients? Clin Transplant. 2017 Oct;31(10). doi: 10.1111/ctr.13036. Epub 2017 Aug 20.

9. Ekser B, Furian L, Broggiato A, Silvestre C, Pierobon ES, Baldan N, Rigotti P.Technical aspects of unilateral dual kidney transplantation from expanded criteria donors: experience of 100 patients. Am J Transplant. 2010 Sep;10(9):2000-7.

10. Rigotti P, Ekser B, Furian L, Baldan N, Valente ML, Boschiero L, Motterlini N, Perna A, Remuzzi G, Ruggenenti P. Outcome of renal transplantation from very old donors. N Engl J Med. 2009 Apr 2;360(14):1464-5.