Giacomo Zanus.pdf

Since 2009 Giacomo Zanus is Deputy Chief  (First Attending) of the Center for Liver Transplantation (adult and pediatric) with a volume of about 70 transplants / year with more than 15% of partial livers. The center also performed 1,000 liver resection including approaches resectional or ablative laparoscopic.

He performed as the first operator than 450 liver transplants including 2 cases of pediatric transplant and more than 450 liver resection by laparotomy and laparoscopic cirrhotic liver and liver healthy for primary and secondary malignant disease and benign solid and cystic.

Particular Research interests and career highlights

Giacomo Zanus works at the Research Group in liver transplantation and hepatobiliary surgery Hepato-biliary Surgery since February 1999 in the following areas of scientific interest:

Hepatocellular carcinoma (clinical prognostic factors and molecular-biological, angiogenesis);

Ischemia-reperfusion (total hepatic vascular exclusion in pork and in small animals, normo- hypothermia, machine perfusion);

Liver regeneration (molecular biology, signal translation, GH-IGF axis);

Technologies Virtual reality hepatic (liver reconstruction and pre-operative planning, virtual reality laparoscopic liver).

Treatment of liver metastases (chemohyperthermia, transplantation);

Immunosuppressive therapy (new immunosuppressants, minimization, tolerance)
Tissue engineering (stem, scaffolds);

He has participated in clinical trials of phase 2 and 4.

1. The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: Results of a randomized, controlled clinical trial. Piano S, Fasolato S, Salinas F, Romano A, Tonon M, Morando F, Cavallin M, Gola E Sticca A, Loregian A, Palù G, Zanus G, Senzolo M, Burra P, Cillo U, Angeli P Hepatology. 2016 Apr;63(4):1299-309. doi: 10.1002/hep.27941. Epub 2015 Aug 4. PMID: 26084406      IF:14.079

2. SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity. Turato C, Cannito S, Simonato D, Villano G, Morello E, Terrin L, Quarta S, Biasiolo A, Ruvoletto M, Martini A, Fasolato S, Zanus G, Cillo U, Gatta A, Parola M, Pontisso P. Sci Rep. 2015 Dec 4;5:17701. doi: 10.1038/srep17701. PMID:26634820     IF: 5.228

3. A method for establishing allocation equity among patients with and without hepatocellular carcinoma on a common liver transplant waiting list. Vitale A, Volk ML, De Feo TM, Burra P, Frigo AC, Ramirez Morales R, De Carlis L, Belli L, Colledan M, Fagiuoli S, Rossi G, Andorno E, Baccarani U, Regalia E, Vivarelli M, Donataccio M, Cillo U; Liver Transplantation North Italy Transplant program (NITp) working group. J Hepatol. 2014 Feb;60(2):290-7. doi: 10.1016/j.jhep.2013.10.010. Epub 2013 Oct 23. Erratum in: J Hepatol. 2014 Jun;60(6):1336. Multipile investigator names added. PMID:24161408    IF:  10.401

4. A prospective policy development to increase split-liver transplantation for 2 adult recipients: results of a 12-year multicenter collaborative study. Aseni P, De Feo TM, De Carlis L, Valente U, Colledan M, Cillo U, Rossi G, Mazzaferro V, Donataccio M, De Fazio N, Andorno E, Burra P; Split-Liver Study Group. Ann Surg. 2014 Jan;259(1):157-65. doi: 10.1097/SLA.0b013e31827da6c9. PMID:23422004    IF:  7.188

5. Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study. Vitale A, Morales RR, Zanus G, Farinati F, Burra P, Angeli P, Frigo AC, Del Poggio P, Rapaccini G, Di Nolfo MA, Benvegnù L, Zoli M, Borzio F, Giannini EG, Caturelli E, Chiaramonte M, Trevisani F, Cillo U; Italian Liver Cancer group. Lancet Oncol. 2011 Jul;12(7):654-62. doi: 10.1016/S1470-2045(11)70144-9. Epub 2011 Jun 16. PMID:21684210      IF:  24.725

6. Continuous recurrence of type 1 hepatorenal syndrome and long-term treatment with terlipressin and albumin: a new exception to MELD score in the allocation system to liver transplantation? Piano S, Morando F, Fasolato S, Cavallin M, Boscato N, Boccagni P, Zanus G, Cillo U, Gatta A, Angeli P. J Hepatol. 2011 Aug;55(2):491-6. doi: 10.1016/j.jhep.2011.02.002. Epub 2011 Feb 18. PMID:21334405     IF:  10.401

7. Intention-to-treat analysis of liver transplantation in selected, aggressively treated HCC patients exceeding the Milan criteria. Cillo U, Vitale A, Grigoletto F, Gringeri E, D'Amico F, Valmasoni M, Brolese A, Zanus G, Srsen N, Carraro A, Burra P, Farinati F, Angeli P, D'Amico DF. Am J Transplant. 2007 Apr;7(4):972-81. PMID:17391137     IF:  6.190

8. Renal failure and bacterial infections in patients with cirrhosis: epidemiology and clinical features. Fasolato S, Angeli P, Dallagnese L, Maresio G, Zola E, Mazza E, Salinas F, Donà S, Fagiuoli S, Sticca A, Zanus G, Cillo U, Frasson I, Destro C, Gatta A. Hepatology. 2007 Jan;45(1):223-9. PMID:17187409     IF:  11.190

9. Complications of radiofrequency thermal ablation in hepatocellular carcinoma: what about "explosive" spread? Angonese C, Baldan A, Cillo U, D'Alessandro A, De Antoni M, De Giorgio M, Masotto A, Marino D, Massani M, Mazzucco M, Miola E, Neri D, Paccagnella D, Pivetta G, Tommasi L, Tremolada F, Tufano A, Zanus G, Farinati F. Gut. 2006 Mar;55(3):435-6. No abstract available. PMID:16474113       IF:  13.319

10. Syngeneic living-donor liver transplantation for hemangioendothelioma: a clinical model for studying liver regeneration. Cillo U, Vitale A, Brolese A, Zanus G, Bassanello M, Montin U, D'Amico F, Ciarleglio FA, Iurilli V, Carraro P, Grigoletto F, Plebani M, D'Amico DF. Am J Transplant. 2005 Sep;5(9):2309-14. PMID:16095515       IF:  6.190

11. Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma. Cillo U, Vitale A, Bassanello M, Boccagni P, Brolese A, Zanus G, Burra P, Fagiuoli S, Farinati F, Rugge M, D'Amico DF. Ann Surg. 2004 Feb;239(2):150-9. PMID:14745321 IF:  7.188

BIRD165014  (2016)  : "Exosome-miRNAs profiling as non-invasive diagnostic tool of aggressive hepatocellular carcinoma."

BIRD172715  (2017): Immunoscore in High and Low grade HCC