Docenti
Career/Employment
Education
1998 Medical degree at the University if Padova
2004 Residency in General Surgery
2008 PhD in Medical and Experimental Sciences, Surgical and Technological Application
(XX course)
from 2004, Clinical Coordinator Hepatobiliary and Liver Transplant Unit (Chief Prof. U. Cillo), Department of General Surgery and Organ Transplantation (University of Padova)
June 2006-2012, Member Scientific Committee of the Inter-Departmental Center of Experimental Surgery at the University of Padova
March 2009, Assistant Professor of Surgery, University of Padova
from 2012 Member of the Scientific Board at the “Associazione Sofia”
2013, Aggregate Professor of Surgery, University of Padova
2013-2018, Secretary at the “30 Nodi per il Fegato” Association
from 2014 Member of the Academic board of PhD at the Clinical and Experimental Sciences course, Department of Medicine, University of Padova
October 2015, Associate Professor of Surgery, University of Padova
From February 2015 Adviser of SIRC (Società Italiana Ricerche in Chirurgia)
From 2015 Elected Member of the Board at the Department of Surgical Oncological and Gastroenterological Sciences (DiSCOG), University of Padova
Visiting Clinical Observer
Hepatobiliopancreatic Service of Memorial Sloan Kettering Cancer Center, New York, NY - USA (Chief Dr. W.R. Jarnagin), 2009
Hepatobiliopancreatic Surgery and Liver Transplant Unit. Mount Sinai Hospital, New York, NY - USA (Chief Dr. M. Schwartz), 2009
Hepatobiliopancreatic Service of Memorial Sloan Kettering Cancer Center, New York, NY - USA (Chief Dr. W.R. Jarnagin), 2011
Mayo Clinic Transplant Center, Rochester, MN - USA (Chief Dr. C. Rosen), 2011
Positions
Associate Professor of General Surgery since October 2015
Research interests and career highlights
Prof. Enrico Gringeri is the Medical Coordinator of the Liver Transplantation Unit at the University of Padova. He based his research on the realization of models of liver surgery and liver transplantation. He was coordinator of research groups in experimental surgery performing hepatic surgery models both on the small and on the large animal. He discussed his graduation thesis on realization of a model of total vascular exclusion for extreme liver resection. During his residency period he performed several liver transplantations in large animal. In particular he studied the pathophysiology of ischemia-reperfusion injury during the liver transplantation process and liver regeneration after liver resection. He published same papers on mechanic liver perfusion using a homemade machine perfusion in both small and large animal models in collaboration with the University of Pavia.
In 2009 and 2011 he spent some period as visiting clinical observer in some specialized Hospitals in the USA (Memorial Sloan Kattering Cancer Center, Mount Sinay Hospital and Mayo Clinic Transplant Center) focusing his studies in liver cancer. Especially in Rochester, at the Mayo Clinic Transplant Center, he had the opportunity to see and study the clinical protocol for liver transplantation for perihilar cholangiocarcinoma. When Prof. Gringeri come back in Italy reproduced the Mayo Clinic protocol for liver transplantation for perihilar cholangiocarcinoma. The protocol is now registered on ClinicalTrials.gov identifier (NCT number): NCT01549795
He ideated and realized a model of ex-situ ex-vivo liver resection using machine perfusion preservation in a pig model. This surgical model was subsequently translated in the clinical setting. He, also ideated and, for the first time, described a model of two stage hepatectomy using microwave ablation of the parenchyma (Gringeri E, Boetto R, DʼAmico FE, Bassi D, Cillo U. Laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS): a minimally invasive first-step approach. Ann Surg. 2015 Feb;261(2):e42-3)
Specific Basic and Clinical/Research Interests:
- Pathophysiology of ischemia-reperfusion injury of the liver
- Liver regeneration and fibrosis
- Biomarkers and oncogenesis
- Liver transplantation for oncological indications
- Minimally invasive liver resection
- Ex-situ liver resection
- Two-stage liver resection
Key publications
1: Vairetti M, Ferrigno A, Gringeri E, Cillo U. Representing Subnormothermic Machine Perfusion in Fatty Livers: The Complete Picture? Am J Transplant. 2017 May;17(5):1421-1422. doi: 10.1111/ajt.14196. Epub 2017 Feb 14. PubMed PMID: 28066998.
2: Cillo U, Gringeri E, Feltracco P, Bassi D, D'Amico FE, Polacco M, Boetto R. Totally Laparoscopic Microwave Ablation and Portal Vein Ligation for Staged Hepatectomy : A New Minimally Invasive Two-Stage Hepatectomy. Ann Surg Oncol. 2015 Aug;22(8):2787-8. doi: 10.1245/s10434-014-4353-7. Epub 2015 Jan 21. PubMed PMID: 25605516.
3: Gringeri E, Boetto R, Bassi D, D'Amico FE, Polacco M, Romano M, Neri D, Feltracco P, Zanus G, Cillo U. Laparoscopic microwave thermal ablation for late recurrence of local hepatocellular carcinoma after liver transplant: case report. Prog Transplant. 2014 Jun;24(2):142-5. doi: 10.7182/pit2014632. PubMed PMID: 24919730.
4: Gringeri E, Boetto R, Bassi D, D'Amico FE, Polacco M, Romano M, Barbieri S, Feltracco P, Spampinato M, Zanus G, Cillo U. Totally laparoscopic caudate lobe resection: technical aspects and literature review. Surg Laparosc Endosc Percutan Tech. 2014 Dec;24(6):e233-6. doi: 10.1097/01.sle.0000442525.26905.6d. Review. PubMed PMID: 24732736.
5: Gringeri E, Boetto R, DʼAmico FE, Bassi D, Cillo U. Laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS): a minimally invasive first-step approach. Ann Surg. 2015 Feb;261(2):e42-3. doi: 10.1097/SLA.0000000000000606. PubMed PMID: 24651131.
6: Gringeri E, Bonsignore P, Bassi D, D'Amico FE, Mescoli C, Polacco M, Buggio M, Luisetto R, Boetto R, Noaro G, Ferrigno A, Boncompagni E, Freitas I, Vairetti MP, Carraro A, Neri D, Cillo U. Subnormothermic machine perfusion for non-heart-beating donor liver grafts preservation in a Swine model: a new strategy to increase the donor pool? Transplant Proc. 2012 Sep;44(7):2026-8. doi: 10.1016/j.transproceed.2012.06.014. PubMed PMID: 22974898.
7: Gringeri E, Polacco M, D'Amico FE, Bassi D, Boetto R, Tuci F, Bonsignore P, Noaro G, D'Amico F, Vitale A, Feltracco P, Barbieri S, Neri D, Zanus G, Cillo U. Liver autotransplantation for the treatment of unresectable hepatic metastasis: an uncommon indication-a case report. Transplant Proc. 2012 Sep;44(7):1930-3. doi: 10.1016/j.transproceed.2012.06.032. PubMed PMID: 22974875.
8: Gringeri E, Bassi D, D'Amico FE, Boetto R, Polacco M, Lodo E, D'Amico F, Vitale A, Boccagni P, Zanus G, Cillo U. Neoadjuvant therapy protocol and liver transplantation in combination with pancreatoduodenectomy for the treatment of hilar cholangiocarcinoma occurring in a case of primary sclerosing cholangitis: case report with a more than 8-year disease-free survival. Transplant Proc. 2011 May;43(4):1187-9. doi: 10.1016/j.transproceed.2011.01.140. PubMed PMID: 21620084.
9: Gringeri E, Polacco M, D'Amico FE, Scopelliti M, Bassi D, Bonsignore P, Luisetto R, Lodo E, Carraro A, Zanus G, Cillo U. A new liver autotransplantation technique using subnormothermic machine perfusion for organ preservation in a porcine model. Transplant Proc. 2011 May;43(4):997-1000. doi: 10.1016/j.transproceed.2011.01.139. PubMed PMID: 21620035.
10: Gringeri E, Carraro A, Tibaldi E, D'Amico FE, Mancon M, Toninello A, Pagano MA, Vio C, Cillo U, Brunati AM. Lyn-mediated mitochondrial tyrosine phosphorylation is required to preserve mitochondrial integrity in early liver regeneration. Biochem J. 2009 Dec 23;425(2):401-12. doi: 10.1042/BJ20090902. PubMed PMID: 19832701.
Funding
2013 - Study of molecular markers that are critical modulators on liver processes such as hepatic regeneration after portal arterialization, cell apoptosis and fibrogenesis in the context of acute/chronic liver injuries.
2015 - A new experimental model of auxiliary partial liver transplantation with portal vein occlusion for the treatment of other than HCC liver tumors.
